A NONSENSE MUTATION IN MOUSE TARDBP AFFECTS TDP43 ALTERNATIVE SPLICING ACTIVITY AND CAUSES LIMB-CLASPING AND BODY TONE DEFECTS.

A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.

Mutations in TARDBP, encoding Tar DNA binding protein-43 (TDP43), cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).Attempts to model TDP43 dysfunction in mice have used knockouts or transgenic overexpressors, which have revealed the difficulties of manipulating TDP43, whose level is tightly controlled by auto-regulation.I

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Research Progress of Fermented Bee-products

Bee-products are the kinds of products which relate to bees, include honey, bee pollen, royal jelly, etc.Fermented bee-product is a kind of added-value product by microbial fermentation.There are many types of fermented bee-products such as honey wine, royal jelly yoghourt and royal jelly beer, etc.Fermented bee-products are rich in nutrition pulle

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